Silent clusters – speak up!

Silent clusters – speak up!

Microorganisms have provided mankind with a multitude of useful compounds ranging from industrial enzymes to anti-cancer compounds and antibiotics. With the aging population, our need for treatment principles against cancer, Alzheimer's disease and metabolic disorders is increasing. Also, the occurrence and spread of antibiotic resistance in pathogenic microorganisms has become one of our main ...

Silent Synapses Speak Up

*Department of Psychiatry The existence of silent or ineffective synapses in the †Department of Cellular and Molecular spinal cordwas proposed over 20 years ago (Wall, 1977), Pharmacology based on experimentally induced rapid changes in the Department of Physiology ability of afferents to evoke single unit activity. However, University of California a limitation of this approach was that it was...

Silent pericentromeric repeats speak out.

Pericentromeres are essential structural components of the chromosome that function to ensure proper sister chromatid segregation during cell division. These chromosomal domains are composed of major satellite DNA repeats whose constitutively heterochromatic structure facilitates kinetochore formation (1). Characteristically demarcated by the silencing histone mark trimethyl-histone-3lysine-9, ...

Time to speak up for research.

As U.S. National Institutes of Health (NIH) Director Francis Collins stated in recent testimony to Congress, “Our nation has never witnessed a time of greater promise for advances in medicine.” Researchers are moving closer to developing a universal flu vaccine, cancer immunotherapy (harnessing the immune system to attack tumor cells) is on the horizon, and the public/private BRAIN initiative w...

Nurses speak up on new ORs design.